There is provided an intelligent fire prevention escape system, which includes a plurality of sensors mounted inside a building, a plurality of escape direction indicating devices, and a server. The sensor is capable of detect environmental factors including smoke, gas, flame, temperature, personnel, and etc. The escape direction indicating device includes an arrow sign lamp and a laser device capable of generating a patterned beam. Therefore, when the building encounters a fire disaster, a processing unit of the server performs an optimal escape route programming computation based on sensing signals of the sensors received by its wireless transceiver unit and a principal structure diagram of the building, so as to dynamically generate escape indicating information and a control signal. Accordingly, the wireless transceiver unit transmits the control signal to the escape direction indicating devices for indicating the escape route in escape channels of the building, and the escape indicating information is transmitted to electronic devices of the personnel in the building via Internet.